Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including astrocytes; strongest in podocytes | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 156 | 0.91 |
| pathways Reactome | 5 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 14292
Sealed predictions
- DLG5 in astrocytes, braak-0.46 (p 0.209) → +0.10 (p 0.807)receipt 14299
- DLG5 in dopamine neurons, braak-0.55 (p 0.123) → -0.58 (p 0.101)receipt 14300
Swarm cases
receipt 14300: DLG5 in dopamine neurons, braak
- power
- full sample -0.39 (p 0.114, n 18), 95% CI -0.72 to +0.10. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.41 (p 0.095, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.59 (p 0.010, n 18). not the mix.
- skeptic
- leave-one-out range -0.51 to -0.31, sign flips 0; without severely affected donors -0.39 (p 0.114, n 18). fragile.
- cell type
- strongest in OPCs: -0.68 (p 0.0021, n 18) vs -0.39 in dopamine neurons. proposing OPCs.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DLG5 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up DLG5 · OPCs · braak: substantia nigra, an independent cohort (already registered)
receipt 14299: DLG5 in astrocytes, braak
- power
- full sample -0.23 (p 0.365, n 18), 95% CI -0.63 to +0.27. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.17 (p 0.493, n 18). does not hold up.
- composition
- astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.21 (p 0.408, n 18). could be the mix.
- skeptic
- leave-one-out range -0.38 to -0.14, sign flips 0; without severely affected donors -0.23 (p 0.365, n 18). fragile.
- cell type
- strongest in OPCs: -0.68 (p 0.0021, n 18) vs -0.23 in astrocytes. proposing OPCs.
- axis
- no measure beats "tracks Braak Lewy-body stage" for DLG5 in astrocytes.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up DLG5 · OPCs · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.53 p 0.062 (needs p < 1.6e-4)
Receipts
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