parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in neutrophils	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 30	0.91
pathways Reactome	1 pathway; mostly vesicle traffic	1.00

No case: the score is under the bar. Receipt 15779

DENND3 in microglia, braak+0.61 (p 0.084) → +0.18 (p 0.648)receipt 15786
DENND3 in dopamine neurons, braak-0.54 (p 0.130) → -0.44 (p 0.232)receipt 15787

receipt 15787: DENND3 in dopamine neurons, braak

power: full sample -0.46 (p 0.057, n 18), 95% CI -0.76 to +0.01. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.48 (p 0.045, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.67 (p 0.0025, n 18). not the mix.
skeptic: leave-one-out range -0.55 to -0.39, sign flips 0; without severely affected donors -0.46 (p 0.057, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for DENND3 in dopamine neurons.

case closed: nothing better to follow up.

receipt 15786: DENND3 in microglia, braak

power: full sample +0.30 (p 0.221, n 18), 95% CI -0.19 to +0.67. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.37 (p 0.130, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.24 (p 0.346, n 18). could be the mix.
skeptic: leave-one-out range +0.20 to +0.36, sign flips 0; without severely affected donors +0.30 (p 0.221, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for DENND3 in microglia.

case closed: nothing better to follow up.

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