Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in vascular endothelial cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.27 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 12896
Sealed predictions
- CASKIN2 in oligodendrocytes, braak-0.41 (p 0.276) → -0.42 (p 0.262)receipt 12904
- CASKIN2 in dopamine neurons, braak+0.31 (p 0.414) → -0.06 (p 0.888)receipt 12905
Swarm cases
receipt 12905: CASKIN2 in dopamine neurons, braak
- power
- full sample +0.07 (p 0.787, n 18), 95% CI -0.41 to +0.52. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.05 (p 0.854, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.00 (p 0.990, n 18). could be the mix.
- skeptic
- leave-one-out range -0.02 to +0.22, sign flips 3; without severely affected donors +0.07 (p 0.787, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CASKIN2 in dopamine neurons.
case closed: nothing better to follow up.
receipt 12904: CASKIN2 in oligodendrocytes, braak
- power
- full sample -0.48 (p 0.042, n 18), 95% CI -0.78 to -0.02. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.54 (p 0.022, n 18). holds up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.51 (p 0.031, n 18). not the mix.
- skeptic
- leave-one-out range -0.59 to -0.42, sign flips 0; without severely affected donors -0.48 (p 0.042, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CASKIN2 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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