parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.05 from other evidence	0.00
cell type Human Protein Atlas	cell type enriched in oligodendrocytes (418 nCPM)	1.00
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 39	0.91
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 4866

CARNS1 in oligodendrocytes, braak+0.10 (p 0.802) → -0.35 (p 0.349)receipt 4873
CARNS1 in dopamine neurons, braak+0.42 (p 0.258) → -0.55 (p 0.123)receipt 4874

receipt 4874: CARNS1 in dopamine neurons, braak

power: full sample +0.11 (p 0.658, n 18), 95% CI -0.37 to +0.55. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.10 (p 0.690, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.16 (p 0.526, n 18). could be the mix.
skeptic: leave-one-out range -0.01 to +0.23, sign flips 2; without severely affected donors +0.11 (p 0.658, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CARNS1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 4873: CARNS1 in oligodendrocytes, braak

power: full sample -0.13 (p 0.597, n 18), 95% CI -0.57 to +0.36. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.18 (p 0.476, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.11 (p 0.658, n 18). could be the mix.
skeptic: leave-one-out range -0.29 to -0.01, sign flips 0; without severely affected donors -0.13 (p 0.597, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CARNS1 in oligodendrocytes.

case closed: nothing better to follow up.

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