Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in choroid plexus epithelial cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 165 | 0.91 |
| pathways Reactome | 4 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 15708
Sealed predictions
- BCAR1 in dopamine neurons, braak-0.54 (p 0.132) → -0.43 (p 0.244)receipt 15716
- BCAR1 in oligodendrocytes, braak-0.03 (p 0.946) → -0.33 (p 0.385)receipt 15715
Swarm cases
receipt 15716: BCAR1 in dopamine neurons, braak
- power
- full sample -0.28 (p 0.265, n 18), 95% CI -0.66 to +0.22. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.28 (p 0.265, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.32 (p 0.191, n 18). could be the mix.
- skeptic
- leave-one-out range -0.41 to -0.19, sign flips 0; without severely affected donors -0.28 (p 0.265, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for BCAR1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 15715: BCAR1 in oligodendrocytes, braak
- power
- full sample -0.13 (p 0.609, n 18), 95% CI -0.56 to +0.36. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.15 (p 0.561, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.16 (p 0.532, n 18). could be the mix.
- skeptic
- leave-one-out range -0.29 to -0.07, sign flips 0; without severely affected donors -0.13 (p 0.609, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for BCAR1 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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