Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

ABCA8

ATP binding cassette subfamily A member 8

translation score 0.48, read 2026-10-31; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.00 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocytes; strongest in fibro-adipogenic progenitors0.75
chemistry
Open Targets		reachable by antibody0.45
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		2 Parkinson's papers of 810.85
pathways
Reactome		1 pathway; mostly other0.30

No case: the score is under the bar. Receipt 15901

Sealed predictions

  1. ABCA8 in dopamine neurons, braak+0.16 (p 0.689) → +0.57 (p 0.109)receipt 15908
  2. ABCA8 in oligodendrocytes, braak+0.11 (p 0.778) → +0.27 (p 0.476)receipt 15907

Swarm cases

receipt 15908: ABCA8 in dopamine neurons, braak

power
full sample +0.43 (p 0.074, n 18), 95% CI -0.04 to +0.75. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.43 (p 0.074, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.36 (p 0.137, n 18). could be the mix.
skeptic
leave-one-out range +0.36 to +0.56, sign flips 0; without severely affected donors +0.43 (p 0.074, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ABCA8 in dopamine neurons.

case closed: nothing better to follow up.

receipt 15907: ABCA8 in oligodendrocytes, braak

power
full sample +0.44 (p 0.066, n 18), 95% CI -0.03 to +0.75. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.53 (p 0.023, n 18). holds up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.53 (p 0.023, n 18). not the mix.
skeptic
leave-one-out range +0.38 to +0.52, sign flips 0; without severely affected donors +0.44 (p 0.066, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ABCA8 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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