Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 9841

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.39, p 0.299). This receipt's hash covers every field on it, plus the hash of receipt 9840, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 9841
    25 Oct 2026, 15:05 UTC

    MAPK8IP1

    dopamine neurons, braak

    predictionMAPK8IP1 in dopamine neurons tracks Braak Lewy-body stage

    registereddd1d8805c766fe74

    discovery-0.39 p=0.299 n=9

    replication-0.21 p=0.581 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.39, p 0.299)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    3b9d1c04089fd94ed6ca4584…
    follows 4108bd420f58…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 9841: MAPK8IP1 in dopamine neurons, braak

power
full sample -0.41 (p 0.093, n 18), 95% CI -0.73 to +0.07. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.41 (p 0.093, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.49 (p 0.037, n 18). not the mix.
skeptic
leave-one-out range -0.62 to -0.36, sign flips 0; without severely affected donors -0.41 (p 0.093, n 18). robust.
cell type
strongest in oligodendrocytes: -0.59 (p 0.0092, n 18) vs -0.41 in dopamine neurons. proposing oligodendrocytes.
axis
no measure beats "tracks Braak Lewy-body stage" for MAPK8IP1 in dopamine neurons.

follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up MAPK8IP1 · oligodendrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.18 p 0.534 (needs p < 2.2e-4)