Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in oligodendrocytes (76 nCPM) | 1.00 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 54 | 0.82 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 9832
Sealed predictions
- MAPK8IP1 in dopamine neurons, braak-0.39 (p 0.299) → -0.21 (p 0.581)receipt 9841
- MAPK8IP1 in oligodendrocytes, braak-0.35 (p 0.362) → -0.51 (p 0.163)receipt 9840
Swarm cases
receipt 9841: MAPK8IP1 in dopamine neurons, braak
- power
- full sample -0.41 (p 0.093, n 18), 95% CI -0.73 to +0.07. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.41 (p 0.093, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.49 (p 0.037, n 18). not the mix.
- skeptic
- leave-one-out range -0.62 to -0.36, sign flips 0; without severely affected donors -0.41 (p 0.093, n 18). robust.
- cell type
- strongest in oligodendrocytes: -0.59 (p 0.0092, n 18) vs -0.41 in dopamine neurons. proposing oligodendrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MAPK8IP1 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up MAPK8IP1 · oligodendrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.18 p 0.534 (needs p < 2.2e-4)
receipt 9840: MAPK8IP1 in oligodendrocytes, braak
- power
- full sample -0.59 (p 0.0092, n 18), 95% CI -0.83 to -0.18. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.56 (p 0.015, n 18). holds up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.60 (p 0.0083, n 18). not the mix.
- skeptic
- leave-one-out range -0.72 to -0.54, sign flips 0; without severely affected donors -0.59 (p 0.0092, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MAPK8IP1 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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