Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 8009

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.14, p 0.714). This receipt's hash covers every field on it, plus the hash of receipt 8008, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 8009
    23 Oct 2026, 23:04 UTC

    HSPA1B

    dopamine neurons, braak

    predictionHSPA1B in dopamine neurons tracks Braak Lewy-body stage

    registered284fe68fb43e6b1b

    discovery+0.14 p=0.714 n=9

    replication+0.02 p=0.965 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.14, p 0.714)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    8087ddb4302d26e28bc41f83…
    follows 37431ccfd393…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 8009: HSPA1B in dopamine neurons, braak

power
full sample +0.03 (p 0.922, n 18), 95% CI -0.45 to +0.49. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.11 (p 0.677, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.23 (p 0.360, n 18). could be the mix.
skeptic
leave-one-out range -0.07 to +0.19, sign flips 7; without severely affected donors +0.03 (p 0.922, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for HSPA1B in dopamine neurons.

case closed: nothing better to follow up.