Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 5548

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.57, p 0.108). This receipt's hash covers every field on it, plus the hash of receipt 5547, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 5548
    21 Oct 2026, 17:30 UTC

    ZNF488

    oligodendrocytes, braak

    predictionZNF488 in oligodendrocytes tracks Braak Lewy-body stage

    registered0dd5b1b048c6e152

    discovery-0.57 p=0.108 n=9

    replication+0.00 p=1.000 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.57, p 0.108)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    5851693fac70e9fe7f296f3a…
    follows f36ce6c5c883…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 5548: ZNF488 in oligodendrocytes, braak

power
full sample -0.19 (p 0.460, n 18), 95% CI -0.60 to +0.31. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.27 (p 0.281, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.28 (p 0.265, n 18). could be the mix.
skeptic
leave-one-out range -0.36 to -0.08, sign flips 0; without severely affected donors -0.19 (p 0.460, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ZNF488 in oligodendrocytes.

case closed: nothing better to follow up.