Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in syncytiotrophoblasts | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 5540
Sealed predictions
- ZNF488 in dopamine neurons, braak+0.21 (p 0.581) → -0.28 (p 0.473)receipt 5549
- ZNF488 in oligodendrocytes, braak-0.57 (p 0.108) → +0.00 (p 1.000)receipt 5548
Swarm cases
receipt 5549: ZNF488 in dopamine neurons, braak
- power
- full sample +0.02 (p 0.928, n 18), 95% CI -0.45 to +0.48. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.02 (p 0.928, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.02 (p 0.949, n 18). could be the mix.
- skeptic
- leave-one-out range -0.09 to +0.13, sign flips 6; without severely affected donors +0.02 (p 0.928, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ZNF488 in dopamine neurons.
case closed: nothing better to follow up.
receipt 5548: ZNF488 in oligodendrocytes, braak
- power
- full sample -0.19 (p 0.460, n 18), 95% CI -0.60 to +0.31. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.27 (p 0.281, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.28 (p 0.265, n 18). could be the mix.
- skeptic
- leave-one-out range -0.36 to -0.08, sign flips 0; without severely affected donors -0.19 (p 0.460, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ZNF488 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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