Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 5032

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.53, p 0.140). This receipt's hash covers every field on it, plus the hash of receipt 5031, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 5032
    21 Oct 2026, 06:30 UTC

    LGI1

    dopamine neurons, braak

    predictionLGI1 in dopamine neurons tracks Braak Lewy-body stage

    registered4ea8cbe628231f1e

    discovery+0.53 p=0.140 n=9

    replication+0.25 p=0.517 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.53, p 0.140)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    f5c7cd216c28d6b6d2a375d1…
    follows 8013502710ce…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 5032: LGI1 in dopamine neurons, braak

power
full sample +0.48 (p 0.044, n 18), 95% CI +0.02 to +0.77. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: +0.52 (p 0.028, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.43 (p 0.077, n 18). could be the mix.
skeptic
leave-one-out range +0.41 to +0.59, sign flips 0; without severely affected donors +0.48 (p 0.044, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for LGI1 in dopamine neurons.

case closed: nothing better to follow up.