Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 4234

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.14, p 0.718). This receipt's hash covers every field on it, plus the hash of receipt 4233, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 4234
    20 Oct 2026, 12:55 UTC

    CPE

    astrocytes, braak

    predictionCPE in astrocytes tracks Braak Lewy-body stage

    registered29a38351d4ed0d65

    discovery-0.14 p=0.718 n=9

    replication+0.32 p=0.407 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.14, p 0.718)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    0775dc916ce8c8708ba2b90c…
    follows 4603b0b951d1…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 4234: CPE in astrocytes, braak

power
full sample +0.01 (p 0.976, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.01 (p 0.983, n 18). does not hold up.
composition
astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.11 (p 0.664, n 18). could be the mix.
skeptic
leave-one-out range -0.10 to +0.14, sign flips 9; without severely affected donors +0.01 (p 0.976, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CPE in astrocytes.

case closed: nothing better to follow up.