parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.06 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in pancreatic islet cells	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	2 Parkinson's trials, 0 stopped	1.00
literature PubMed	8 Parkinson's papers of 8,474	0.71
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 4227

receipt 4235: CPE in dopamine neurons, braak

power: full sample +0.31 (p 0.214, n 18), 95% CI -0.19 to +0.68. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.29 (p 0.239, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.30 (p 0.221, n 18). could be the mix.
skeptic: leave-one-out range +0.22 to +0.46, sign flips 0; without severely affected donors +0.31 (p 0.214, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CPE in dopamine neurons.

case closed: nothing better to follow up.

receipt 4234: CPE in astrocytes, braak

power: full sample +0.01 (p 0.976, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.01 (p 0.983, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.11 (p 0.664, n 18). could be the mix.
skeptic: leave-one-out range -0.10 to +0.14, sign flips 9; without severely affected donors +0.01 (p 0.976, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CPE in astrocytes.

case closed: nothing better to follow up.

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