Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 2886

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.17, p 0.656). This receipt's hash covers every field on it, plus the hash of receipt 2885, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 2886
    19 Oct 2026, 07:31 UTC

    UGCG

    dopamine neurons, braak

    predictionUGCG in dopamine neurons tracks Braak Lewy-body stage

    registered42eaabc39a65bf70

    discovery-0.17 p=0.656 n=9

    replication+0.02 p=0.964 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.17, p 0.656)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    9e0b913bf9631c15adeed007…
    follows 6f9764d52e1a…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 2886: UGCG in dopamine neurons, braak

power
full sample -0.24 (p 0.328, n 18), 95% CI -0.64 to +0.25. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.34 (p 0.173, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.29 (p 0.235, n 18). could be the mix.
skeptic
leave-one-out range -0.37 to -0.15, sign flips 0; without severely affected donors -0.24 (p 0.328, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for UGCG in dopamine neurons.

case closed: nothing better to follow up.