Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 1744

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.54, p 0.136). This receipt's hash covers every field on it, plus the hash of receipt 1743, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 1744
    18 Oct 2026, 05:32 UTC

    MUC19

    dopamine neurons, braak

    predictionMUC19 in dopamine neurons tracks Braak Lewy-body stage

    registered1a93be792c740466

    discovery+0.54 p=0.136 n=9

    replication+0.38 p=0.309 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.54, p 0.136)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    0ef117c1934b9f0cd80329f3…
    follows da0bf2c32b23…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 1744: MUC19 in dopamine neurons, braak

power
full sample +0.47 (p 0.047, n 18), 95% CI +0.01 to +0.77. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: +0.44 (p 0.067, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.37 (p 0.127, n 18). could be the mix.
skeptic
leave-one-out range +0.42 to +0.66, sign flips 0; without severely affected donors +0.47 (p 0.047, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for MUC19 in dopamine neurons.

case closed: nothing better to follow up.