Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.39 (overall 0.24) | 0.39 |
| cell type Human Protein Atlas | cell type enriched outside the brain (salivary acinar cells) | 0.10 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 4 Parkinson's papers of 109 | 0.79 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 1737
Sealed predictions
- MUC19 in dopamine neurons, braak+0.54 (p 0.136) → +0.38 (p 0.309)receipt 1744
Swarm cases
receipt 1744: MUC19 in dopamine neurons, braak
- power
- full sample +0.47 (p 0.047, n 18), 95% CI +0.01 to +0.77. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.44 (p 0.067, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.37 (p 0.127, n 18). could be the mix.
- skeptic
- leave-one-out range +0.42 to +0.66, sign flips 0; without severely affected donors +0.47 (p 0.047, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MUC19 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts