Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 16971

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.04, p 0.912). This receipt's hash covers every field on it, plus the hash of receipt 16970, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 16971
    01 Nov 2026, 04:22 UTC

    NIPA1

    oligodendrocytes, braak

    predictionNIPA1 in oligodendrocytes tracks Braak Lewy-body stage

    registered6def5f8f1cd6bf85

    discovery+0.04 p=0.912 n=9

    replication-0.21 p=0.581 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.04, p 0.912)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    71cf075f4cc318d70eaaaa26…
    follows d7b935109dd8…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 16971: NIPA1 in oligodendrocytes, braak

power
full sample -0.12 (p 0.640, n 18), 95% CI -0.55 to +0.37. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.12 (p 0.640, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.10 (p 0.702, n 18). could be the mix.
skeptic
leave-one-out range -0.25 to -0.01, sign flips 0; without severely affected donors -0.12 (p 0.640, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for NIPA1 in oligodendrocytes.

case closed: nothing better to follow up.