Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 16962

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.05, p 0.893). This receipt's hash covers every field on it, plus the hash of receipt 16961, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 16962
    01 Nov 2026, 04:11 UTC

    PCK2

    microglia, braak

    predictionPCK2 in microglia tracks Braak Lewy-body stage

    registered20174130c220566b

    discovery+0.05 p=0.893 n=9

    replication+0.26 p=0.493 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.05, p 0.893)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    1d4b59085a21e4f03cb659f7…
    follows d01f0c2a1a8d…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 16962: PCK2 in microglia, braak

power
full sample +0.16 (p 0.532, n 18), 95% CI -0.33 to +0.58. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.29 (p 0.235, n 18). does not hold up.
composition
microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.28 (p 0.254, n 18). could be the mix.
skeptic
leave-one-out range +0.03 to +0.26, sign flips 0; without severely affected donors +0.16 (p 0.532, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PCK2 in microglia.

case closed: nothing better to follow up.