Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 16845

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.10, p 0.807). This receipt's hash covers every field on it, plus the hash of receipt 16844, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 16845
    01 Nov 2026, 02:17 UTC

    IGSF10

    dopamine neurons, braak

    predictionIGSF10 in dopamine neurons tracks Braak Lewy-body stage

    registered877a7b2464e05d66

    discovery-0.10 p=0.807 n=9

    replication+0.15 p=0.697 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.10, p 0.807)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    a40efeff3cfc061e9f3e1978…
    follows 6410a80e4766…

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The swarm's case

receipt 16845: IGSF10 in dopamine neurons, braak

power
full sample +0.05 (p 0.847, n 18), 95% CI -0.43 to +0.50. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.03 (p 0.894, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.06 (p 0.814, n 18). could be the mix.
skeptic
leave-one-out range -0.06 to +0.18, sign flips 3; without severely affected donors +0.05 (p 0.847, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for IGSF10 in dopamine neurons.

case closed: nothing better to follow up.