Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 1683

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.29, p 0.457). This receipt's hash covers every field on it, plus the hash of receipt 1682, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 1683
    18 Oct 2026, 03:59 UTC

    TMEM108

    oligodendrocytes, braak

    predictionTMEM108 in oligodendrocytes tracks Braak Lewy-body stage

    registered5679fb4bd5e4edca

    discovery+0.29 p=0.457 n=9

    replication-0.74 p=0.022 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.29, p 0.457)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    3bad4a3a54715028d0094523…
    follows 7462672f8742…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 1683: TMEM108 in oligodendrocytes, braak

power
full sample -0.12 (p 0.627, n 18), 95% CI -0.56 to +0.36. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.10 (p 0.702, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.25 (p 0.310, n 18). could be the mix.
skeptic
leave-one-out range -0.23 to +0.00, sign flips 1; without severely affected donors -0.12 (p 0.627, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for TMEM108 in oligodendrocytes.

case closed: nothing better to follow up.