Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.40 (overall 0.25) | 0.40 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in rod photoreceptor cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 15 | 0.82 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 1676
Sealed predictions
- TMEM108 in dopamine neurons, braak+0.26 (p 0.502) → +0.42 (p 0.265)receipt 1684
- TMEM108 in oligodendrocytes, braak+0.29 (p 0.457) → -0.74 (p 0.022)receipt 1683
Swarm cases
receipt 1684: TMEM108 in dopamine neurons, braak
- power
- full sample +0.40 (p 0.101, n 18), 95% CI -0.08 to +0.73. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.38 (p 0.116, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.30 (p 0.232, n 18). could be the mix.
- skeptic
- leave-one-out range +0.34 to +0.58, sign flips 0; without severely affected donors +0.40 (p 0.101, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TMEM108 in dopamine neurons.
case closed: nothing better to follow up.
receipt 1683: TMEM108 in oligodendrocytes, braak
- power
- full sample -0.12 (p 0.627, n 18), 95% CI -0.56 to +0.36. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.10 (p 0.702, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.25 (p 0.310, n 18). could be the mix.
- skeptic
- leave-one-out range -0.23 to +0.00, sign flips 1; without severely affected donors -0.12 (p 0.627, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TMEM108 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
loading the receipts