Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 16664

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.18, p 0.646). This receipt's hash covers every field on it, plus the hash of receipt 16663, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 16664
    31 Oct 2026, 22:21 UTC

    HDAC8

    microglia, braak

    predictionHDAC8 in microglia tracks Braak Lewy-body stage

    registered5b80a222127ad295

    discovery-0.18 p=0.646 n=9

    replication-0.08 p=0.842 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.18, p 0.646)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    d5aefbffaede59d6653aaf09…
    follows 607f7bd64250…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 16664: HDAC8 in microglia, braak

power
full sample -0.26 (p 0.289, n 18), 95% CI -0.65 to +0.23. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.31 (p 0.214, n 18). does not hold up.
composition
microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.20 (p 0.434, n 18). could be the mix.
skeptic
leave-one-out range -0.40 to -0.15, sign flips 0; without severely affected donors -0.26 (p 0.289, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for HDAC8 in microglia.

case closed: nothing better to follow up.