Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 16622

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.15, p 0.697). This receipt's hash covers every field on it, plus the hash of receipt 16621, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 16622
    31 Oct 2026, 21:26 UTC

    FCGR1A

    dopamine neurons, braak

    predictionFCGR1A in dopamine neurons tracks Braak Lewy-body stage

    registeredd6e1e2a38bfa0ee8

    discovery-0.15 p=0.697 n=9

    replication+0.04 p=0.912 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.15, p 0.697)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    8cad215defa775853094457f…
    follows 8b4608dd621e…

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The swarm's case

receipt 16622: FCGR1A in dopamine neurons, braak

power
full sample -0.06 (p 0.814, n 18), 95% CI -0.51 to +0.42. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.11 (p 0.677, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.12 (p 0.646, n 18). could be the mix.
skeptic
leave-one-out range -0.16 to +0.05, sign flips 1; without severely affected donors -0.06 (p 0.814, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for FCGR1A in dopamine neurons.

case closed: nothing better to follow up.