Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (hofbauer cells) | 0.10 |
| chemistry Open Targets | compounds already reach it: mdx-447 | 0.81 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 146 | 0.91 |
| pathways Reactome | 8 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 16615
Sealed predictions
- FCGR1A in dopamine neurons, braak-0.15 (p 0.697) → +0.04 (p 0.912)receipt 16622
Swarm cases
receipt 16622: FCGR1A in dopamine neurons, braak
- power
- full sample -0.06 (p 0.814, n 18), 95% CI -0.51 to +0.42. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.11 (p 0.677, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.12 (p 0.646, n 18). could be the mix.
- skeptic
- leave-one-out range -0.16 to +0.05, sign flips 1; without severely affected donors -0.06 (p 0.814, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for FCGR1A in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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