Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 16361

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.14, p 0.716). This receipt's hash covers every field on it, plus the hash of receipt 16360, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 16361
    31 Oct 2026, 15:29 UTC

    CNKSR2

    dopamine neurons, braak

    predictionCNKSR2 in dopamine neurons tracks Braak Lewy-body stage

    registeredddca103f25a01d98

    discovery+0.14 p=0.716 n=9

    replication+0.40 p=0.284 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.14, p 0.716)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    0db6110f106e4689c94aca32…
    follows b02e008ba2c1…

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The swarm's case

receipt 16361: CNKSR2 in dopamine neurons, braak

power
full sample +0.23 (p 0.365, n 18), 95% CI -0.27 to +0.63. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.46 (p 0.055, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.45 (p 0.062, n 18). could be the mix.
skeptic
leave-one-out range +0.11 to +0.37, sign flips 0; without severely affected donors +0.23 (p 0.365, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CNKSR2 in dopamine neurons.

case closed: nothing better to follow up.