Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in rod photoreceptor cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 7 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 16354
Sealed predictions
- CNKSR2 in dopamine neurons, braak+0.14 (p 0.716) → +0.40 (p 0.284)receipt 16361
Swarm cases
receipt 16361: CNKSR2 in dopamine neurons, braak
- power
- full sample +0.23 (p 0.365, n 18), 95% CI -0.27 to +0.63. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.46 (p 0.055, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.45 (p 0.062, n 18). could be the mix.
- skeptic
- leave-one-out range +0.11 to +0.37, sign flips 0; without severely affected donors +0.23 (p 0.365, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CNKSR2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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