Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 16309

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.11, p 0.787). This receipt's hash covers every field on it, plus the hash of receipt 16308, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 16309
    31 Oct 2026, 14:15 UTC

    PLCL1

    dopamine neurons, braak

    predictionPLCL1 in dopamine neurons tracks Braak Lewy-body stage

    registeredd24bfe8f7c10c945

    discovery+0.11 p=0.787 n=9

    replication+0.55 p=0.122 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.11, p 0.787)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    4525d18d9a3d04e46a22b17d…
    follows 576b1abee167…

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The swarm's case

receipt 16309: PLCL1 in dopamine neurons, braak

power
full sample +0.17 (p 0.509, n 18), 95% CI -0.33 to +0.59. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.12 (p 0.633, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.15 (p 0.561, n 18). could be the mix.
skeptic
leave-one-out range +0.06 to +0.30, sign flips 0; without severely affected donors +0.17 (p 0.509, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PLCL1 in dopamine neurons.

case closed: nothing better to follow up.