Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 15778

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.28, p 0.472). This receipt's hash covers every field on it, plus the hash of receipt 15777, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 15778
    31 Oct 2026, 02:33 UTC

    ABCC4

    dopamine neurons, braak

    predictionABCC4 in dopamine neurons tracks Braak Lewy-body stage

    registered5386104ca66a51cd

    discovery+0.28 p=0.472 n=9

    replication+0.03 p=0.929 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.28, p 0.472)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    b9804be07d9abe3492571bbf…
    follows 93cbca4b7c87…

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The swarm's case

receipt 15778: ABCC4 in dopamine neurons, braak

power
full sample +0.15 (p 0.549, n 18), 95% CI -0.34 to +0.58. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.08 (p 0.761, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.17 (p 0.493, n 18). could be the mix.
skeptic
leave-one-out range +0.07 to +0.28, sign flips 0; without severely affected donors +0.15 (p 0.549, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ABCC4 in dopamine neurons.

case closed: nothing better to follow up.