parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in renal collecting duct intercalated cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 663	0.91
pathways Reactome	4 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 15739

ABCC4 in microglia, braak+0.11 (p 0.779) → -0.09 (p 0.821)receipt 15777
ABCC4 in dopamine neurons, braak+0.28 (p 0.472) → +0.03 (p 0.929)receipt 15778

receipt 15778: ABCC4 in dopamine neurons, braak

power: full sample +0.15 (p 0.549, n 18), 95% CI -0.34 to +0.58. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.08 (p 0.761, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.17 (p 0.493, n 18). could be the mix.
skeptic: leave-one-out range +0.07 to +0.28, sign flips 0; without severely affected donors +0.15 (p 0.549, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ABCC4 in dopamine neurons.

case closed: nothing better to follow up.

receipt 15777: ABCC4 in microglia, braak

power: full sample +0.02 (p 0.935, n 18), 95% CI -0.45 to +0.48. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.02 (p 0.949, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.18 (p 0.465, n 18). could be the mix.
skeptic: leave-one-out range -0.08 to +0.19, sign flips 7; without severely affected donors +0.02 (p 0.935, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ABCC4 in microglia.

case closed: nothing better to follow up.

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