Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 15173

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.00, p 1.000). This receipt's hash covers every field on it, plus the hash of receipt 15172, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 15173
    30 Oct 2026, 13:42 UTC

    ADH6

    dopamine neurons, braak

    predictionADH6 in dopamine neurons tracks Braak Lewy-body stage

    registered78f8a33ccdf53f2b

    discovery+0.00 p=1.000 n=9

    replication+0.55 p=0.121 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.00, p 1.000)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    7cbeaa4efb0e2cab09f2ca4b…
    follows e3523e64a451…

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The swarm's case

receipt 15173: ADH6 in dopamine neurons, braak

power
full sample +0.27 (p 0.277, n 18), 95% CI -0.22 to +0.65. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.24 (p 0.332, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.24 (p 0.332, n 18). could be the mix.
skeptic
leave-one-out range +0.17 to +0.37, sign flips 0; without severely affected donors +0.27 (p 0.277, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ADH6 in dopamine neurons.

case closed: nothing better to follow up.