Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 14791

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.62, p 0.073). This receipt's hash covers every field on it, plus the hash of receipt 14790, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 14791
    30 Oct 2026, 03:54 UTC

    HSPB2

    dopamine neurons, braak

    predictionHSPB2 in dopamine neurons tracks Braak Lewy-body stage

    registered181ef02abe1dd786

    discovery-0.62 p=0.073 n=9

    replication+0.07 p=0.855 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.62, p 0.073)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    f53ef0d10ae31de9169f87ce…
    follows 0e522b33e46a…

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The swarm's case

receipt 14791: HSPB2 in dopamine neurons, braak

power
full sample -0.29 (p 0.239, n 18), 95% CI -0.67 to +0.20. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.28 (p 0.265, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.30 (p 0.225, n 18). could be the mix.
skeptic
leave-one-out range -0.39 to -0.20, sign flips 0; without severely affected donors -0.29 (p 0.239, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for HSPB2 in dopamine neurons.

case closed: nothing better to follow up.