Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 14787

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.10, p 0.802). This receipt's hash covers every field on it, plus the hash of receipt 14786, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 14787
    30 Oct 2026, 03:48 UTC

    GUCY1A1

    dopamine neurons, braak

    predictionGUCY1A1 in dopamine neurons tracks Braak Lewy-body stage

    registered964f8d9d810baa56

    discovery+0.10 p=0.802 n=9

    replication+0.63 p=0.068 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.10, p 0.802)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    e6c4a9d781b9141a550ee504…
    follows aa997170cdda…

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The swarm's case

receipt 14787: GUCY1A1 in dopamine neurons, braak

power
full sample +0.30 (p 0.225, n 18), 95% CI -0.19 to +0.67. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.30 (p 0.232, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.28 (p 0.261, n 18). could be the mix.
skeptic
leave-one-out range +0.20 to +0.46, sign flips 0; without severely affected donors +0.30 (p 0.225, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for GUCY1A1 in dopamine neurons.

case closed: nothing better to follow up.