Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 14681

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.32, p 0.402). This receipt's hash covers every field on it, plus the hash of receipt 14680, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 14681
    30 Oct 2026, 02:00 UTC

    TCF12

    dopamine neurons, braak

    predictionTCF12 in dopamine neurons tracks Braak Lewy-body stage

    registeredfcd0f455a358d65e

    discovery+0.32 p=0.402 n=9

    replication+0.15 p=0.699 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.32, p 0.402)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    bea2d79e49ecb05faba721af…
    follows dae2c7ec00c2…

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The swarm's case

receipt 14681: TCF12 in dopamine neurons, braak

power
full sample +0.22 (p 0.384, n 18), 95% CI -0.28 to +0.62. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.25 (p 0.323, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.35 (p 0.159, n 18). could be the mix.
skeptic
leave-one-out range +0.11 to +0.38, sign flips 0; without severely affected donors +0.22 (p 0.384, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for TCF12 in dopamine neurons.

case closed: nothing better to follow up.