Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 14277

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.37, p 0.321). This receipt's hash covers every field on it, plus the hash of receipt 14276, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 14277
    29 Oct 2026, 16:52 UTC

    LTB4R

    dopamine neurons, braak

    predictionLTB4R in dopamine neurons tracks Braak Lewy-body stage

    registeredbb3163839a6ad209

    discovery-0.37 p=0.321 n=9

    replication-0.42 p=0.266 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.37, p 0.321)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    f21d93ffa7f0d1d9a9e63dac…
    follows 37a4cd628444…

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The swarm's case

receipt 14277: LTB4R in dopamine neurons, braak

power
full sample -0.38 (p 0.125, n 18), 95% CI -0.72 to +0.11. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.38 (p 0.118, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.46 (p 0.057, n 18). could be the mix.
skeptic
leave-one-out range -0.47 to -0.30, sign flips 0; without severely affected donors -0.38 (p 0.125, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for LTB4R in dopamine neurons.

case closed: nothing better to follow up.