Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 14134

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.33, p 0.389). This receipt's hash covers every field on it, plus the hash of receipt 14133, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 14134
    29 Oct 2026, 13:34 UTC

    POLR2F

    dopamine neurons, braak

    predictionPOLR2F in dopamine neurons tracks Braak Lewy-body stage

    registered16ad1a38a49a1d6a

    discovery-0.33 p=0.389 n=9

    replication-0.38 p=0.315 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.33, p 0.389)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    cd4f3fa6dc609f5a1e1d8ee0…
    follows c8172a05c1e9…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 14134: POLR2F in dopamine neurons, braak

power
full sample -0.31 (p 0.211, n 18), 95% CI -0.68 to +0.18. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.28 (p 0.261, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.39 (p 0.111, n 18). could be the mix.
skeptic
leave-one-out range -0.40 to -0.22, sign flips 0; without severely affected donors -0.31 (p 0.211, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for POLR2F in dopamine neurons.

case closed: nothing better to follow up.