Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 14113

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.49, p 0.182). This receipt's hash covers every field on it, plus the hash of receipt 14112, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 14113
    29 Oct 2026, 13:06 UTC

    HMGCS2

    dopamine neurons, braak

    predictionHMGCS2 in dopamine neurons tracks Braak Lewy-body stage

    registereda96f3c5448929af7

    discovery-0.49 p=0.182 n=9

    replication+0.32 p=0.400 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.49, p 0.182)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    fd7bbbc6df7e063f6ae26269…
    follows 5a50c68065b3…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 14113: HMGCS2 in dopamine neurons, braak

power
full sample -0.16 (p 0.521, n 18), 95% CI -0.58 to +0.33. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.18 (p 0.476, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.34 (p 0.164, n 18). could be the mix.
skeptic
leave-one-out range -0.28 to -0.05, sign flips 0; without severely affected donors -0.16 (p 0.521, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for HMGCS2 in dopamine neurons.

case closed: nothing better to follow up.