Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 1411

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.48, p 0.195). This receipt's hash covers every field on it, plus the hash of receipt 1410, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 1411
    17 Oct 2026, 22:11 UTC

    PBX2

    microglia, braak

    predictionPBX2 in microglia tracks Braak Lewy-body stage

    registeredd4ec39cd8d4c2a3c

    discovery-0.48 p=0.195 n=9

    replication+0.08 p=0.838 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.48, p 0.195)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    745ee97053a67a2a3bc2ad45…
    follows 9c8393cd0835…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 1411: PBX2 in microglia, braak

power
full sample -0.22 (p 0.374, n 18), 95% CI -0.62 to +0.27. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.19 (p 0.444, n 18). does not hold up.
composition
microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.15 (p 0.544, n 18). could be the mix.
skeptic
leave-one-out range -0.39 to -0.11, sign flips 0; without severely affected donors -0.22 (p 0.374, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PBX2 in microglia.

case closed: nothing better to follow up.