Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 13397

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.58, p 0.099). This receipt's hash covers every field on it, plus the hash of receipt 13396, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 13397
    28 Oct 2026, 21:14 UTC

    C6orf141

    dopamine neurons, braak

    predictionC6orf141 in dopamine neurons tracks Braak Lewy-body stage

    registeredf85f031eac1dc46b

    discovery-0.58 p=0.099 n=9

    replication+0.34 p=0.375 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.58, p 0.099)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    c68fab054cf01ce540587a28…
    follows 71d22fa1fd7c…

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The swarm's case

receipt 13397: C6orf141 in dopamine neurons, braak

power
full sample -0.00 (p 0.997, n 18), 95% CI -0.47 to +0.47. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.16 (p 0.538, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.13 (p 0.597, n 18). could be the mix.
skeptic
leave-one-out range -0.13 to +0.10, sign flips 8; without severely affected donors -0.00 (p 0.997, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for C6orf141 in dopamine neurons.

case closed: nothing better to follow up.