Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 13200

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.42, p 0.266). This receipt's hash covers every field on it, plus the hash of receipt 13199, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 13200
    28 Oct 2026, 16:40 UTC

    ISYNA1

    dopamine neurons, braak

    predictionISYNA1 in dopamine neurons tracks Braak Lewy-body stage

    registereda481f2265ad632c0

    discovery-0.42 p=0.266 n=9

    replication-0.41 p=0.273 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.42, p 0.266)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    3a07024881a925a76c6512c0…
    follows e9c4f2042231…

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The swarm's case

receipt 13200: ISYNA1 in dopamine neurons, braak

power
full sample -0.41 (p 0.089, n 18), 95% CI -0.74 to +0.07. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.42 (p 0.084, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.41 (p 0.093, n 18). could be the mix.
skeptic
leave-one-out range -0.51 to -0.34, sign flips 0; without severely affected donors -0.41 (p 0.089, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ISYNA1 in dopamine neurons.

case closed: nothing better to follow up.