Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 1318

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.59, p 0.098). This receipt's hash covers every field on it, plus the hash of receipt 1317, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 1318
    17 Oct 2026, 19:59 UTC

    PKN1

    dopamine neurons, braak

    predictionPKN1 in dopamine neurons tracks Braak Lewy-body stage

    registered99a291f98f078f14

    discovery-0.59 p=0.098 n=9

    replication-0.68 p=0.042 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.59, p 0.098)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    76a474fac3da34ad41ba0caa…
    follows dcab75dd9eba…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 1318: PKN1 in dopamine neurons, braak

power
full sample -0.64 (p 0.0040, n 18), 95% CI -0.85 to -0.25. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.68 (p 0.0020, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.69 (p 0.0014, n 18). not the mix.
skeptic
leave-one-out range -0.75 to -0.60, sign flips 0; without severely affected donors -0.64 (p 0.0040, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PKN1 in dopamine neurons.

case closed: nothing better to follow up.