Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.30 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 146 | 0.91 |
| pathways Reactome | 6 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 1312
Sealed predictions
- PKN1 in dopamine neurons, braak-0.59 (p 0.098) → -0.68 (p 0.042)receipt 1318
Swarm cases
receipt 1318: PKN1 in dopamine neurons, braak
- power
- full sample -0.64 (p 0.0040, n 18), 95% CI -0.85 to -0.25. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.68 (p 0.0020, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.69 (p 0.0014, n 18). not the mix.
- skeptic
- leave-one-out range -0.75 to -0.60, sign flips 0; without severely affected donors -0.64 (p 0.0040, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PKN1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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