Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 13107

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.03, p 0.929). This receipt's hash covers every field on it, plus the hash of receipt 13106, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 13107
    28 Oct 2026, 14:31 UTC

    CYBA

    dopamine neurons, braak

    predictionCYBA in dopamine neurons tracks Braak Lewy-body stage

    registeredb45c13aa5676b109

    discovery+0.03 p=0.929 n=9

    replication-0.62 p=0.073 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.03, p 0.929)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    81905a7e6085d3bf9e15febd…
    follows 421bd9f01cc5…

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The swarm's case

receipt 13107: CYBA in dopamine neurons, braak

power
full sample -0.32 (p 0.194, n 18), 95% CI -0.69 to +0.17. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.34 (p 0.173, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.28 (p 0.258, n 18). could be the mix.
skeptic
leave-one-out range -0.46 to -0.22, sign flips 0; without severely affected donors -0.32 (p 0.194, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CYBA in dopamine neurons.

case closed: nothing better to follow up.