Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 13050

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.39, p 0.297). This receipt's hash covers every field on it, plus the hash of receipt 13049, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 13050
    28 Oct 2026, 13:17 UTC

    POLR2L

    dopamine neurons, braak

    predictionPOLR2L in dopamine neurons tracks Braak Lewy-body stage

    registeredbc827255d2a809ca

    discovery+0.39 p=0.297 n=9

    replication+0.31 p=0.414 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.39, p 0.297)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    3e8edac23c5087fcd1eb3b06…
    follows 4f9aa1a59fbd…

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The swarm's case

receipt 13050: POLR2L in dopamine neurons, braak

power
full sample +0.36 (p 0.148, n 18), 95% CI -0.13 to +0.71. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.38 (p 0.125, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.40 (p 0.101, n 18). could be the mix.
skeptic
leave-one-out range +0.28 to +0.52, sign flips 0; without severely affected donors +0.36 (p 0.148, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for POLR2L in dopamine neurons.

case closed: nothing better to follow up.