Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 22 | 0.91 |
| pathways Reactome | 56 pathways; mostly mitochondrial quality control | 1.00 |
No case: the score is under the bar. Receipt 13043
Sealed predictions
- POLR2L in dopamine neurons, braak+0.39 (p 0.297) → +0.31 (p 0.414)receipt 13050
Swarm cases
receipt 13050: POLR2L in dopamine neurons, braak
- power
- full sample +0.36 (p 0.148, n 18), 95% CI -0.13 to +0.71. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.38 (p 0.125, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.40 (p 0.101, n 18). could be the mix.
- skeptic
- leave-one-out range +0.28 to +0.52, sign flips 0; without severely affected donors +0.36 (p 0.148, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for POLR2L in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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