Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12848

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.27, p 0.484). This receipt's hash covers every field on it, plus the hash of receipt 12847, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12848
    28 Oct 2026, 08:48 UTC

    ZNF440

    dopamine neurons, braak

    predictionZNF440 in dopamine neurons tracks Braak Lewy-body stage

    registered2580d0bbab4177a7

    discovery+0.27 p=0.484 n=9

    replication-0.25 p=0.520 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.27, p 0.484)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    d71e6b7810a0ba95792ad334…
    follows 5c1d54f29194…

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The swarm's case

receipt 12848: ZNF440 in dopamine neurons, braak

power
full sample +0.24 (p 0.337, n 18), 95% CI -0.26 to +0.64. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.24 (p 0.328, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.36 (p 0.142, n 18). could be the mix.
skeptic
leave-one-out range +0.13 to +0.35, sign flips 0; without severely affected donors +0.24 (p 0.337, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ZNF440 in dopamine neurons.

case closed: nothing better to follow up.