Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12790

A sealed prediction that did not hold.

did not replicate (discovery -0.76 p 0.017; held-out +0.02 p 0.964). This receipt's hash covers every field on it, plus the hash of receipt 12789, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12790
    28 Oct 2026, 07:28 UTC

    AGRP

    dopamine neurons, braak

    predictionAGRP in dopamine neurons tracks Braak Lewy-body stage

    registeredcf07d1050c63bc95

    discovery-0.76 p=0.017 n=9

    replication+0.02 p=0.964 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery -0.76 p 0.017; held-out +0.02 p 0.964)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    504f91dc243b30abde9cacdd…
    follows f1bd34d047ee…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 12790: AGRP in dopamine neurons, braak

power
full sample -0.21 (p 0.398, n 18), 95% CI -0.62 to +0.28. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.20 (p 0.424, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.39 (p 0.109, n 18). could be the mix.
skeptic
leave-one-out range -0.35 to -0.10, sign flips 0; without severely affected donors -0.21 (p 0.398, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for AGRP in dopamine neurons.

case closed: nothing better to follow up.