Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (epididymal principal cells) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 2,276 | 0.82 |
| pathways Reactome | 1 pathway; mostly iron and oxidative stress | 0.80 |
No case: the score is under the bar. Receipt 12784
Sealed predictions
- AGRP in dopamine neurons, braak-0.76 (p 0.017) → +0.02 (p 0.964)receipt 12790
Swarm cases
receipt 12790: AGRP in dopamine neurons, braak
- power
- full sample -0.21 (p 0.398, n 18), 95% CI -0.62 to +0.28. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.20 (p 0.424, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.39 (p 0.109, n 18). could be the mix.
- skeptic
- leave-one-out range -0.35 to -0.10, sign flips 0; without severely affected donors -0.21 (p 0.398, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for AGRP in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts