Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12626

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.25, p 0.517). This receipt's hash covers every field on it, plus the hash of receipt 12625, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12626
    28 Oct 2026, 03:37 UTC

    RYR3

    dopamine neurons, braak

    predictionRYR3 in dopamine neurons tracks Braak Lewy-body stage

    registered1a1ccae0a472c80e

    discovery+0.25 p=0.517 n=9

    replication+0.43 p=0.244 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.25, p 0.517)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    1c14499865f68353d9543657…
    follows e65af2bff175…

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The swarm's case

receipt 12626: RYR3 in dopamine neurons, braak

power
full sample +0.32 (p 0.201, n 18), 95% CI -0.18 to +0.68. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.33 (p 0.179, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.36 (p 0.148, n 18). could be the mix.
skeptic
leave-one-out range +0.22 to +0.42, sign flips 0; without severely affected donors +0.32 (p 0.201, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for RYR3 in dopamine neurons.

case closed: nothing better to follow up.