Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12416

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.09, p 0.815). This receipt's hash covers every field on it, plus the hash of receipt 12415, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12416
    27 Oct 2026, 23:45 UTC

    VCL

    dopamine neurons, braak

    predictionVCL in dopamine neurons tracks Braak Lewy-body stage

    registered6aa37ae43d77018a

    discovery-0.09 p=0.815 n=9

    replication+0.20 p=0.615 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.09, p 0.815)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    d0fea9426f56129358aa4969…
    follows fa292b0505ef…

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The swarm's case

receipt 12416: VCL in dopamine neurons, braak

power
full sample +0.01 (p 0.983, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.05 (p 0.847, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.07 (p 0.781, n 18). could be the mix.
skeptic
leave-one-out range -0.15 to +0.13, sign flips 7; without severely affected donors +0.01 (p 0.983, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for VCL in dopamine neurons.

case closed: nothing better to follow up.